BAIT

ATP1B1

ATP1B

ATPase, Na+/K+ transporting, beta 1 polypeptide

GO Process (25)

GO Function (5)

GO Component (6)

Gene Ontology Biological Process

blood coagulation [TAS]

cardiac muscle contraction [ISS]

cell communication by electrical coupling involved in cardiac conduction [TAS]

cellular calcium ion homeostasis [ISS]

cellular potassium ion homeostasis [IDA]

cellular sodium ion homeostasis [IDA]

ion transmembrane transport [TAS]

leukocyte migration [TAS]

membrane repolarization [IDA]

membrane repolarization during cardiac muscle cell action potential [IC]

positive regulation of ATP catabolic process [IDA]

positive regulation of ATPase activity [IDA]

positive regulation of calcium:sodium antiporter activity [ISS]

positive regulation of potassium ion import [IDA]

positive regulation of potassium ion transmembrane transporter activity [IDA]

positive regulation of sodium ion export from cell [IDA]

potassium ion import [IDA]

protein localization to plasma membrane [IDA]

protein stabilization [IDA, ISS]

protein transport into plasma membrane raft [TAS]

regulation of cardiac muscle contraction by calcium ion signaling [ISS]

regulation of gene expression [ISS]

relaxation of cardiac muscle [ISS]

sodium ion export from cell [IDA]

transmembrane transport [TAS]

Gene Ontology Molecular Function

ATPase activator activity [IDA]
ATPase binding [IPI]
MHC class II protein complex binding [IDA]
protein binding [IPI]
sodium:potassium-exchanging ATPase activity [IDA]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

intercalated disc [ISS]

plasma membrane [IDA, TAS]

sarcolemma [ISS]

sodium:potassium-exchanging ATPase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

LRIF1

C1orf103, RIF1, RP11-96K19.1

ligand dependent nuclear receptor interacting factor 1

GO Process (0)

GO Function (1)

GO Component (3)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

microtubule organizing center [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human protein-protein interaction network: a resource for annotating the proteome.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoez E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]

Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]

Quantitative Score

2.0 [Confidence Score]

Throughput

High Throughput

Curated By

BioGRID