BAIT
ATP6AP1
16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3, XX-FW83563B9.4
ATPase, H+ transporting, lysosomal accessory protein 1
GO Process (8)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- establishment of organelle localization [ISS]
- pH reduction [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of bone resorption [ISS]
- positive regulation of exocytosis [ISS]
- positive regulation of osteoblast differentiation [ISS]
- positive regulation of osteoclast development [ISS]
- proton transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANG
ALS9, HEL168, RAA1, RNASE4, RNASE5
angiogenin, ribonuclease, RNase A family, 5
GO Process (21)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- actin filament polymerization [ISS]
- activation of phospholipase A2 activity [IMP]
- activation of phospholipase C activity [IMP]
- activation of protein kinase B activity [IMP]
- angiogenesis [IDA, IMP, TAS]
- cell communication [NAS]
- cell migration [IMP]
- diacylglycerol biosynthetic process [IDA]
- homeostatic process [NAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- nucleic acid phosphodiester bond hydrolysis [TAS]
- oocyte maturation [NAS]
- ovarian follicle development [NAS]
- placenta development [NAS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein secretion [IDA, ISS]
- rRNA transcription [IMP]
- response to hormone [IDA]
- response to hypoxia [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 2.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID