BAIT

ELL3

elongation factor RNA polymerase II-like 3

GO Process (9)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

DNA-templated transcription, elongation [IDA]

positive regulation of DNA-templated transcription, elongation [IDA]

positive regulation of transcription from RNA polymerase II promoter [IDA]

regulation of epithelial to mesenchymal transition [ISS]

snRNA transcription from RNA polymerase II promoter [IMP]

spermatogenesis [NAS]

stem cell differentiation [ISS]

transcription elongation from RNA polymerase II promoter [IDA]

transcription from RNA polymerase II promoter [ISS]

Gene Ontology Molecular Function

enhancer binding [ISS]

Gene Ontology Cellular Component

nucleolus [IDA]

nucleoplasm [IDA]

transcription elongation factor complex [IDA, NAS]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

FTH1

FHC, FTH, FTHL6, HFE5, PIG15, PLIF, OK/SW-cl.84

ferritin, heavy polypeptide 1

GO Process (8)

GO Function (2)

GO Component (4)

Gene Ontology Biological Process

cellular iron ion homeostasis [TAS]

immune response [ISS]

intracellular sequestering of iron ion [IDA]

membrane organization [TAS]

negative regulation of cell proliferation [ISS]

negative regulation of fibroblast proliferation [IDA]

post-Golgi vesicle-mediated transport [TAS]

transmembrane transport [TAS]

Gene Ontology Molecular Function

iron ion binding [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

intracellular ferritin complex [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human protein-protein interaction network: a resource for annotating the proteome.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoez E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]

Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]

Quantitative Score

2.0 [Confidence Score]

Throughput

High Throughput

Curated By

BioGRID