BAIT
HMOX1
HMOX1D, HO-1, HSP32, bK286B10, CTA-286B10.6
heme oxygenase (decycling) 1
GO Process (31)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [TAS]
- cell death [ISS]
- cellular iron ion homeostasis [TAS]
- cellular response to hypoxia [IEP]
- endothelial cell proliferation [TAS]
- erythrocyte homeostasis [IMP]
- excretion [IC]
- heme catabolic process [IDA, TAS]
- heme oxidation [IDA]
- intracellular signal transduction [TAS]
- iron ion homeostasis [IDA, IMP]
- low-density lipoprotein particle clearance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of leukocyte migration [TAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- porphyrin-containing compound metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine biosynthetic process [TAS]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of vasodilation [IC]
- protein homooligomerization [IDA]
- regulation of angiogenesis [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISS]
- response to hydrogen peroxide [ISS]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [TAS]
- transmembrane transport [TAS]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC16A7
MCT2
solute carrier family 16 (monocarboxylate transporter), member 7
GO Process (4)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID