BAIT
SYNDIG1
C20orf39, DSPC2, IFITMD5, TMEM90B, RP5-860P4.1
synapse differentiation inducing 1
GO Process (3)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FFAR2
FFA2R, GPR43
free fatty acid receptor 2
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- cell surface pattern recognition receptor signaling pathway [IMP]
- cellular response to fatty acid [IDA]
- fat cell differentiation [ISS]
- glucose homeostasis [ISS]
- leukocyte chemotaxis involved in inflammatory response [ISS]
- lipid storage [ISS]
- mucosal immune response [ISS]
- positive regulation of acute inflammatory response to non-antigenic stimulus [ISS]
- positive regulation of chemokine production [ISS]
- positive regulation of cytokine production involved in immune response [ISS]
- positive regulation of interleukin-8 secretion [IMP]
- regulation of acute inflammatory response [ISS]
- regulation of peptide hormone secretion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID