BAIT
PLLP
PMLP, TM4SF11
plasmolipin
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
HOXA1
BSAS, HOX1, HOX1F
homeobox A1
GO Process (16)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- abducens nerve formation [IMP]
- anatomical structure morphogenesis [IMP]
- artery development [IMP]
- artery morphogenesis [IMP]
- cochlea development [IMP]
- cochlea morphogenesis [IMP]
- cognition [IDA]
- embryonic neurocranium morphogenesis [IMP]
- inner ear development [IMP]
- multicellular organismal development [TAS]
- neuromuscular process [IDA]
- optokinetic behavior [IDA]
- outer ear morphogenesis [IDA]
- regulation of behavior [IDA]
- semicircular canal formation [IMP]
- sensory perception of sound [IDA]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID