BAIT
AQP9
AQP-9, HsT17287, SSC1
aquaporin 9
GO Process (21)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- amine transport [IDA]
- carboxylic acid transport [TAS]
- cellular response to cAMP [IEP]
- cellular water homeostasis [IBA]
- excretion [TAS]
- glycerol transport [TAS]
- immune response [TAS]
- ion transmembrane transport [IBA]
- metabolic process [TAS]
- polyol transport [IDA]
- purine nucleobase transport [IDA]
- pyrimidine nucleobase transport [IDA]
- pyrimidine-containing compound transmembrane transport [IDA]
- response to mercury ion [IDA]
- response to organic substance [IDA]
- response to osmotic stress [TAS]
- transmembrane transport [TAS]
- transport [TAS]
- urea transmembrane transport [IBA]
- water homeostasis [NAS]
- water transport [IDA, TAS]
Gene Ontology Molecular Function- amine transmembrane transporter activity [TAS]
- carboxylic acid transmembrane transporter activity [TAS]
- glycerol channel activity [EXP, IBA]
- polyol transmembrane transporter activity [TAS]
- porin activity [NAS]
- purine nucleobase transmembrane transporter activity [IDA]
- pyrimidine nucleobase transmembrane transporter activity [IDA]
- urea transmembrane transporter activity [IBA]
- water channel activity [IDA]
- water transmembrane transporter activity [TAS]
- amine transmembrane transporter activity [TAS]
- carboxylic acid transmembrane transporter activity [TAS]
- glycerol channel activity [EXP, IBA]
- polyol transmembrane transporter activity [TAS]
- porin activity [NAS]
- purine nucleobase transmembrane transporter activity [IDA]
- pyrimidine nucleobase transmembrane transporter activity [IDA]
- urea transmembrane transporter activity [IBA]
- water channel activity [IDA]
- water transmembrane transporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
APOD
apolipoprotein D
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- aging [NAS]
- angiogenesis [NAS]
- brain development [ISS]
- glucose metabolic process [IDA]
- lipid metabolic process [IDA]
- lipid transport [NAS]
- negative regulation of T cell migration [IDA]
- negative regulation of cytokine production involved in inflammatory response [IDA]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of lipoprotein lipid oxidation [IDA]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IMP]
- peripheral nervous system axon regeneration [ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to reactive oxygen species [IDA]
- tissue regeneration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID