BAIT
TDGF1
CR, CRGF, CRIPTO
teratocarcinoma-derived growth factor 1
GO Process (22)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- anterior/posterior axis specification, embryo [ISS]
- cell differentiation [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hepatocyte growth factor stimulus [IDA]
- cellular response to interferon-gamma [IDA]
- cellular response to interleukin-6 [IDA]
- cellular response to tumor necrosis factor [IDA]
- embryo development [TAS]
- epidermal growth factor receptor signaling pathway [IDA]
- heart development [IDA]
- mammary gland development [TAS]
- morphogenesis of a branching structure [TAS]
- negative regulation of apoptotic process [IDA]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA, TAS]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANG
ALS9, HEL168, RAA1, RNASE4, RNASE5
angiogenin, ribonuclease, RNase A family, 5
GO Process (21)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- actin filament polymerization [ISS]
- activation of phospholipase A2 activity [IMP]
- activation of phospholipase C activity [IMP]
- activation of protein kinase B activity [IMP]
- angiogenesis [IDA, IMP, TAS]
- cell communication [NAS]
- cell migration [IMP]
- diacylglycerol biosynthetic process [IDA]
- homeostatic process [NAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- nucleic acid phosphodiester bond hydrolysis [TAS]
- oocyte maturation [NAS]
- ovarian follicle development [NAS]
- placenta development [NAS]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein secretion [IDA, ISS]
- rRNA transcription [IMP]
- response to hormone [IDA]
- response to hypoxia [IDA, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 2.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID