BAIT
NCALD
neurocalcin delta
GO Process (2)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LIF
CDF, DIA, HILDA, MLPLI
leukemia inhibitory factor
GO Process (17)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- leukemia inhibitory factor signaling pathway [IDA]
- multicellular organismal development [TAS]
- negative regulation of hormone secretion [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of histone H3-K27 acetylation [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein localization to nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- regulation of metanephric nephron tubule epithelial cell differentiation [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID