BAIT
ARHGDIA
GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cellular component movement [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell adhesion [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- semaphorin-plexin signaling pathway [ISS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FEN1
FEN-1, MF1, RAD2
flap structure-specific endonuclease 1
GO Process (14)
GO Function (10)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA, IMP]
- DNA catabolic process, exonucleolytic [TAS]
- DNA repair [TAS]
- DNA replication [TAS]
- DNA replication, removal of RNA primer [IDA]
- DNA strand elongation involved in DNA replication [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA]
- UV protection [TAS]
- base-excision repair [TAS]
- double-strand break repair [TAS]
- mitotic cell cycle [TAS]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
Gene Ontology Molecular Function- 5'-3' exonuclease activity [IDA]
- 5'-flap endonuclease activity [IDA, IMP]
- DNA binding [IMP]
- RNA-DNA hybrid ribonuclease activity [IDA]
- damaged DNA binding [TAS]
- double-stranded DNA binding [TAS]
- double-stranded DNA exodeoxyribonuclease activity [TAS]
- endonuclease activity [TAS]
- exonuclease activity [TAS]
- protein binding [IPI]
- 5'-3' exonuclease activity [IDA]
- 5'-flap endonuclease activity [IDA, IMP]
- DNA binding [IMP]
- RNA-DNA hybrid ribonuclease activity [IDA]
- damaged DNA binding [TAS]
- double-stranded DNA binding [TAS]
- double-stranded DNA exodeoxyribonuclease activity [TAS]
- endonuclease activity [TAS]
- exonuclease activity [TAS]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 3.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID