BAIT

HSPB1

CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27

heat shock 27kDa protein 1

Alzheimer's Disease Project

GO Process (21)

GO Function (7)

GO Component (8)

Gene Ontology Biological Process

RNA metabolic process [TAS]

cellular component movement [TAS]

cellular response to vascular endothelial growth factor stimulus [IMP]

gene expression [TAS]

intracellular signal transduction [IMP]

mRNA metabolic process [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]

negative regulation of protein kinase activity [ISS]

platelet aggregation [IMP]

positive regulation of angiogenesis [IMP]

positive regulation of blood vessel endothelial cell migration [IMP]

positive regulation of endothelial cell chemotaxis [IMP]

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]

positive regulation of interleukin-1 beta production [ISS]

positive regulation of tumor necrosis factor biosynthetic process [ISS]

regulation of I-kappaB kinase/NF-kappaB signaling [ISS]

regulation of translational initiation [TAS]

response to unfolded protein [NAS]

response to virus [IEP]

retina homeostasis [IEP]

Gene Ontology Molecular Function

identical protein binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase C binding [ISS]
protein kinase C inhibitor activity [ISS]
protein kinase binding [IPI]
ubiquitin binding [ISS]

Gene Ontology Cellular Component

cytoplasm [IDA, TAS]

cytoskeleton [TAS]

extracellular space [IDA]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

proteasome complex [ISS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

LRIF1

C1orf103, RIF1, RP11-96K19.1

ligand dependent nuclear receptor interacting factor 1

GO Process (0)

GO Function (1)

GO Component (3)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

actin cytoskeleton [IDA]

microtubule organizing center [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human protein-protein interaction network: a resource for annotating the proteome.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoez E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]

Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]

Quantitative Score

3.0 [Confidence Score]

Throughput

High Throughput

Curated By

BioGRID