BAIT
ARPC3
ARC21, p21-Arc
actin related protein 2/3 complex, subunit 3, 21kDa
GO Process (4)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LATS1
WARTS, wts
large tumor suppressor kinase 1
GO Process (11)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- cytoplasmic sequestering of protein [IMP]
- hippo signaling [IDA, TAS]
- hormone-mediated signaling pathway [ISS]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of actin filament polymerization [IDA]
- regulation of protein complex assembly [IMP]
- sister chromatid segregation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID