PDE4D
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- adrenergic receptor signaling pathway [ISS]
- adrenergic receptor signaling pathway involved in positive regulation of heart rate [IC]
- cAMP catabolic process [IDA, IGI, IMP]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to epinephrine stimulus [IDA]
- establishment of endothelial barrier [ISS]
- negative regulation of heart contraction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of interleukin-5 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of heart rate [ISS]
- regulation of receptor activity [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
Gene Ontology Molecular Function- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
COIL
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PDE4D COIL | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID