BAIT

RPA2

REPA2, RP-A p32, RP-A p34, RPA32, RP4-547C9.3

replication protein A2, 32kDa

Fanconi Anemia Project

GO Process (20)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

DNA recombinase assembly [TAS]

DNA repair [TAS]

DNA replication [IDA, IMP, TAS]

DNA strand elongation involved in DNA replication [TAS]

G1/S transition of mitotic cell cycle [TAS]

base-excision repair [IDA]

double-strand break repair [TAS]

double-strand break repair via homologous recombination [IMP, TAS]

mismatch repair [IMP]

mitotic G1 DNA damage checkpoint [IMP]

mitotic cell cycle [TAS]

nucleotide-excision repair [IMP, TAS]

nucleotide-excision repair, DNA damage removal [TAS]

nucleotide-excision repair, DNA gap filling [TAS]

regulation of DNA damage checkpoint [IMP]

regulation of double-strand break repair via homologous recombination [IMP]

telomere maintenance [IMP, TAS]

telomere maintenance via recombination [TAS]

telomere maintenance via semi-conservative replication [TAS]

transcription-coupled nucleotide-excision repair [TAS]

Gene Ontology Molecular Function

damaged DNA binding [IDA]
enzyme binding [IPI]
protein binding [IPI]
protein phosphatase binding [IPI]
single-stranded DNA binding [IC, IDA, ISS]
ubiquitin protein ligase binding [IPI]

Gene Ontology Cellular Component

DNA replication factor A complex [IDA, IPI]

chromosome, telomeric region [IDA]

nucleoplasm [IDA, TAS]

site of double-strand break [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

TUBB2A

CDCBM5, TUBB, TUBB2, dJ40E16.7

tubulin, beta 2A class IIa

GO Process (3)

GO Function (0)

GO Component (4)

Gene Ontology Biological Process

'de novo' posttranslational protein folding [TAS]

cellular protein metabolic process [TAS]

protein folding [TAS]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

microtubule [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human protein-protein interaction network: a resource for annotating the proteome.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoez E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]

Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]

Quantitative Score

5.0 [Confidence Score]

Throughput

High Throughput

Curated By

BioGRID