BAIT
SEC22A
SEC22L2
SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KCNJ2
ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3
potassium inwardly-rectifying channel, subfamily J, member 2
GO Process (16)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cardiac muscle cell action potential involved in contraction [IMP]
- cellular potassium ion homeostasis [TAS]
- membrane depolarization during cardiac muscle cell action potential [TAS]
- membrane repolarization during action potential [IMP]
- membrane repolarization during cardiac muscle cell action potential [IMP, TAS]
- potassium ion import [IDA]
- potassium ion transmembrane transport [IDA]
- potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IDA]
- regulation of resting membrane potential [TAS]
- regulation of skeletal muscle contraction via regulation of action potential [IMP]
- relaxation of cardiac muscle [IMP]
- relaxation of skeletal muscle [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID