BAIT
GJA8
CAE, CAE1, CTRCT1, CX50, CZP1, MP70
gap junction protein, alpha 8, 50kDa
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
APOD
apolipoprotein D
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- aging [NAS]
- angiogenesis [NAS]
- brain development [ISS]
- glucose metabolic process [IDA]
- lipid metabolic process [IDA]
- lipid transport [NAS]
- negative regulation of T cell migration [IDA]
- negative regulation of cytokine production involved in inflammatory response [IDA]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of lipoprotein lipid oxidation [IDA]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IMP]
- peripheral nervous system axon regeneration [ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to reactive oxygen species [IDA]
- tissue regeneration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID