BAIT
PACSIN1
SDPI, RP11-375E1__A.1
protein kinase C and casein kinase substrate in neurons 1
GO Process (8)
GO Function (3)
GO Component (10)
Gene Ontology Biological Process
- cytoskeleton organization [IBA]
- establishment of protein localization to plasma membrane [ISS]
- membrane tubulation [IDA]
- neuron projection morphogenesis [IBA, ISS]
- positive regulation of dendrite development [ISS]
- protein localization to membrane [ISS]
- regulation of endocytosis [IBA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLEKHF2
EAPF, PHAFIN2, ZFYVE18
pleckstrin homology domain containing, family F (with FYVE domain) member 2
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID