BAIT
KRT34
HA4, Ha-4, KRTHA4, hHa4
keratin 34
GO Process (1)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
ADRA2C
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
adrenoceptor alpha 2C
GO Process (13)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of MAPK activity by adrenergic receptor signaling pathway [IDA]
- activation of protein kinase B activity [IDA]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [IDA]
- negative regulation of epinephrine secretion [NAS]
- negative regulation of norepinephrine secretion [NAS, TAS]
- platelet activation [TAS]
- positive regulation of neuron differentiation [IDA]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID