BAIT
PER2
FASPS, FASPS1
period circadian clock 2
GO Process (22)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- circadian regulation of translation [ISS]
- circadian rhythm [TAS]
- fatty acid metabolic process [ISS]
- gluconeogenesis [ISS]
- glycogen biosynthetic process [ISS]
- histone H3 deacetylation [ISS]
- lactate biosynthetic process [ISS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of fat cell proliferation [ISS]
- negative regulation of protein ubiquitination [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of transcription regulatory region DNA binding [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- regulation of cell cycle [ISS]
- regulation of circadian rhythm [ISS]
- regulation of glutamate uptake involved in transmission of nerve impulse [ISS]
- regulation of insulin secretion [ISS]
- regulation of neurogenesis [ISS]
- regulation of vasoconstriction [ISS]
- response to ischemia [ISS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
LOC400927-CSNK1E
LOC400927-CSNK1E readthrough
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID