BAIT
COX5B
COXVB
cytochrome c oxidase subunit Vb
GO Process (5)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
CDC42EP2
BORG1, CEP2
CDC42 effector protein (Rho GTPase binding) 2
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton organization [IDA]
- actin filament organization [NAS]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of protein complex assembly [TAS]
- positive regulation of pseudopodium assembly [IDA]
- regulation of cell shape [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID