BAIT
GLRA1
HKPX1, STHE
glycine receptor, alpha 1
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- chloride transmembrane transport [IDA, IGI, IMP]
- chloride transport [IDA]
- ion transmembrane transport [TAS]
- ion transport [IDA]
- muscle contraction [IMP]
- negative regulation of transmission of nerve impulse [IMP]
- neuropeptide signaling pathway [IDA]
- positive regulation of acrosome reaction [IMP]
- regulation of membrane potential [IMP]
- startle response [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAGED1
DLXIN-1, NRAGE, PRO2292
melanoma antigen family D, 1
GO Process (8)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- circadian regulation of gene expression [ISS]
- negative regulation of epithelial cell proliferation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID