BAIT
CDKN2B
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, RP11-149I2.1
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
GO Process (18)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cellular response to extracellular stimulus [IMP]
- cellular response to nutrient [IMP]
- gene expression [TAS]
- megakaryocyte differentiation [IEP]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA, NAS]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RUSC1
NESCA, RP11-21N7.4
RUN and SH3 domain containing 1
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID