BAIT
STOM
BND7, EPB7, EPB72, RP11-342H3.1
stomatin
GO Process (1)
GO Function (0)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
PTCH1
BCNS, HPE7, NBCCS, PTC, PTC1, PTCH, PTCH11, RP11-435O5.3
patched 1
GO Process (21)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID