BAIT
GRM2
GLUR2, GPRC1B, MGLUR2, mGlu2
glutamate receptor, metabotropic 2
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC30A8
ZNT8, ZnT-8
solute carrier family 30 (zinc transporter), member 8
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- cellular zinc ion homeostasis [ISS]
- glucose homeostasis [ISS]
- insulin secretion [IMP]
- positive regulation of insulin secretion [ISS]
- regulation of sequestering of zinc ion [ISS]
- regulation of vesicle-mediated transport [ISS]
- response to glucose [IMP]
- sequestering of zinc ion [IDA]
- transmembrane transport [TAS]
- zinc ion transmembrane transport [IDA]
- zinc ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID