BAIT
DLG1
DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg
discs, large homolog 1 (Drosophila)
GO Process (17)
GO Function (11)
GO Component (17)
Gene Ontology Biological Process
- actin filament organization [IDA]
- axon guidance [TAS]
- cortical actin cytoskeleton organization [IDA]
- dephosphorylation [TAS]
- endothelial cell proliferation [IDA]
- establishment or maintenance of cell polarity [TAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of mitotic cell cycle [IMP]
- nucleotide phosphorylation [TAS]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of potassium ion transport [IDA]
- protein localization to plasma membrane [IMP, TAS]
- regulation of membrane potential [IDA]
- regulation of sodium ion transmembrane transport [TAS]
- single organismal cell-cell adhesion [IDA]
- synaptic transmission [TAS]
- tight junction assembly [IDA]
Gene Ontology Molecular Function- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- L27 domain binding [IPI]
- cytoskeletal protein binding [TAS]
- guanylate kinase activity [TAS]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- phosphatase binding [IPI]
- phosphoprotein phosphatase activity [TAS]
- potassium channel regulator activity [IDA, NAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MPP7-DLG1-LIN7 complex [IDA]
- basolateral plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- cytosol [TAS]
- endoplasmic reticulum [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [TAS]
- intercalated disc [TAS]
- microtubule [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [TAS]
- tight junction [IDA]
Homo sapiens
PREY
GRIN1
GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1, RP11-350O14.1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
GO Process (14)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- calcium ion homeostasis [ISS]
- calcium ion transmembrane transport [IDA]
- cation transport [IDA]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- propylene metabolic process [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [IDA]
- response to ethanol [IDA]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- cell surface [ISS]
- dendrite [IDA]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- integral component of plasma membrane [IDA]
- neuron projection [ISS]
- plasma membrane [TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IBA, ISS]
- synapse [ISS]
- synaptic cleft [ISS]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors.
SAP97 interacts with AMPA receptors (AMPARs) and NMDA receptors (NMDARs) during sorting and trafficking to synapses. Here we addressed how SAP97 distinguishes between AMPARs and NMDARs and what role the adaptor/scaffold protein, CASK, plays in the process. Using intramolecular SAP97 Foerster resonance energy transfer sensors, we demonstrated that SAP97 is in "extended" or "compact" conformations in vivo. SAP97 conformation was ... [more]
J. Neurosci. Jul. 17, 2013; 33(29);12067-76 [Pubmed: 23864692]
Throughput
- Low Throughput
Curated By
- BioGRID