BAIT
ATF4
CREB-2, CREB2, TAXREB67, TXREB
activating transcription factor 4
GO Process (20)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular amino acid metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IMP]
- circadian regulation of gene expression [ISS]
- endoplasmic reticulum unfolded protein response [TAS]
- gluconeogenesis [ISS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- negative regulation of oxidative stress-induced neuron death [IGI]
- positive regulation of apoptotic process [TAS]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISS]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS, NAS]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of transcription, DNA-templated [ISS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- core promoter sequence-specific DNA binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IC]
- sequence-specific DNA binding transcription factor activity [ISS, TAS]
- transcription regulatory region DNA binding [IDA, TAS]
- DNA binding [IDA, ISS]
- core promoter sequence-specific DNA binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IC]
- sequence-specific DNA binding transcription factor activity [ISS, TAS]
- transcription regulatory region DNA binding [IDA, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CEBPB
C/EBPbeta, CRP2, IL-6DBP, LAP, LIP, NF-IL6, NF-M, Nfil6, RP24-151H6.1
CCAAT/enhancer binding protein (C/EBP), beta
GO Process (19)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brown fat cell differentiation [IMP]
- cellular response to amino acid stimulus [IDA]
- embryonic placenta development [IGI]
- fat cell differentiation [IDA, IGI]
- mammary gland epithelial cell differentiation [IMP]
- mammary gland epithelial cell proliferation [IMP]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [IDA]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of interleukin-6 biosynthetic process [IDA]
- regulation of transcription involved in cell fate commitment [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to endoplasmic reticulum stress [ISO]
- response to lipopolysaccharide [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- glucocorticoid receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- transcription factor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- glucocorticoid receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.
The crystal structure of the heterodimer formed by the basic leucine zipper (bZIP) domains of activating transcription factor-4 (ATF4) and CCAAT box/enhancer-binding protein beta (C/EBP beta), from two different bZIP transcription factor families, has been determined and refined to 2.6 A. The structure shows that the heterodimer forms an asymmetric coiled-coil. Even in the absence of DNA, the basic region ... [more]
J. Biol. Chem. Jan. 05, 2001; 276(1);505-13 [Pubmed: 11018027]
Throughput
- Low Throughput
Curated By
- BioGRID