SHH
Gene Ontology Biological Process
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [IDA]
- T cell differentiation in thymus [ISS]
- androgen metabolic process [ISS]
- apoptotic signaling pathway [ISS]
- axon guidance [ISS]
- branching involved in ureteric bud morphogenesis [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell development [ISS]
- cell fate specification [ISS]
- cell-cell signaling [ISS]
- central nervous system development [ISS]
- cerebellar granule cell precursor proliferation [ISS]
- determination of left/right asymmetry in lateral mesoderm [ISS]
- dorsal/ventral pattern formation [ISS]
- embryo development [ISS]
- embryonic digit morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic pattern specification [TAS]
- epithelial-mesenchymal signaling involved in prostate gland development [IDA]
- forebrain development [ISS]
- heart development [ISS]
- heart looping [ISS]
- hindbrain development [ISS]
- lung development [ISS]
- lymphoid progenitor cell differentiation [IMP]
- male genitalia development [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- metanephros development [ISS]
- midbrain development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell differentiation [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cholesterol efflux [ISS]
- negative regulation of kidney smooth muscle cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of ureter smooth muscle cell differentiation [ISS]
- negative thymic T cell selection [ISS]
- neural crest cell migration [ISS]
- neuroblast proliferation [ISS]
- neuron fate commitment [ISS]
- pattern specification process [ISS]
- patterning of blood vessels [ISS]
- polarity specification of anterior/posterior axis [ISS]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of cell division [IDA]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of hh target transcription factor activity [ISS]
- positive regulation of immature T cell proliferation in thymus [ISS]
- positive regulation of kidney smooth muscle cell differentiation [ISS]
- positive regulation of mesenchymal cell proliferation involved in ureter development [ISS]
- positive regulation of sclerotome development [IDA]
- positive regulation of smoothened signaling pathway [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of ureter smooth muscle cell differentiation [ISS]
- positive thymic T cell selection [ISS]
- prostate gland development [ISS]
- regulation of cell proliferation [ISS]
- regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- regulation of odontogenesis [ISS]
- regulation of protein localization to nucleus [IDA]
- regulation of proteolysis [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [ISS]
- stem cell development [ISS]
- thymus development [ISS]
- vasculogenesis [ISS]
- ventral midline development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTCH1
Gene Ontology Biological Process
- brain development [ISS]
- cellular response to cholesterol [IMP, ISS]
- dorsal/ventral pattern formation [ISS]
- embryonic limb morphogenesis [ISS]
- limb morphogenesis [IMP]
- negative regulation of multicellular organism growth [ISS]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of smoothened signaling pathway [ISS, TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural plate axis specification [ISS]
- neural tube patterning [IMP]
- organ morphogenesis [ISS]
- pharyngeal system development [IMP]
- positive regulation of cholesterol efflux [IDA]
- protein processing [ISS]
- protein targeting to plasma membrane [IDA]
- regulation of smoothened signaling pathway [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1, and correlates with therapeutic resistance. Mechanistically, TSPAN8 interacts with PTCH1 and inhibits the degradation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SHH PTCH1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID