BAIT

KCTD16

potassium channel tetramerization domain containing 16
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

GABBR2

GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
gamma-aminobutyric acid (GABA) B receptor, 2
Homo sapiens

Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.

Zuo H, Glaaser I, Zhao Y, Kurinov I, Mosyak L, Wang H, Liu J, Park J, Frangaj A, Sturchler E, Zhou M, McDonald P, Geng Y, Slesinger PA, Fan QR

Metabotropic GABAB receptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABAB receptor complexes contain the principal subunits GABAB1 and GABAB2, which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization domain-containing proteins (KCTDs). KCTDs interact with GABAB receptors and modify the kinetics of GABAB receptor signaling. Little is known about the molecular mechanism ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 23, 2018; 116(17);8370-8379 [Pubmed: 30971491]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
KCTD16 GABBR2
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
2747011

Curated By

  • BioGRID