BAIT

KCTD16

potassium channel tetramerization domain containing 16
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

KCTD16

potassium channel tetramerization domain containing 16
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor.

Zuo H, Glaaser I, Zhao Y, Kurinov I, Mosyak L, Wang H, Liu J, Park J, Frangaj A, Sturchler E, Zhou M, McDonald P, Geng Y, Slesinger PA, Fan QR

Metabotropic GABAB receptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABAB receptor complexes contain the principal subunits GABAB1 and GABAB2, which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization domain-containing proteins (KCTDs). KCTDs interact with GABAB receptors and modify the kinetics of GABAB receptor signaling. Little is known about the molecular mechanism ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 23, 2018; 116(17);8370-8379 [Pubmed: 30971491]

Throughput

  • Low Throughput

Additional Notes

  • assayed using SEC (size exclusion chromatography)

Curated By

  • BioGRID