BAIT
FBXW8
FBW6, FBW8, FBX29, FBXO29, FBXW6
F-box and WD repeat domain containing 8
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP2A2
ADTAB, CLAPA2, HIP-9, HIP9, HYPJ
adaptor-related protein complex 2, alpha 2 subunit
GO Process (9)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.
3-M primordial dwarfism is an inherited disease characterized by severe pre- and postnatal growth retardation and by mutually exclusive mutations in three genes, CUL7, OBSL1, and CCDC8. The mechanism underlying 3-M dwarfism is not clear. We showed here that CCDC8, derived from a retrotransposon Gag protein in placental mammals, exclusively localized on the plasma membrane and was phosphorylated by CK2 ... [more]
J. Clin. Invest. Jul. 25, 2019; 130();4393-4407 [Pubmed: 31343991]
Throughput
- High Throughput
Curated By
- BioGRID