BAIT
OBSL1
obscurin-like 1
GO Process (7)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MTMR2
CMT4B, CMT4B1
myotubularin related protein 2
GO Process (11)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
- dendritic spine maintenance [ISS]
- negative regulation of endocytosis [ISS]
- negative regulation of excitatory postsynaptic membrane potential [ISS]
- negative regulation of receptor catabolic process [ISS]
- negative regulation of receptor internalization [ISS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA]
- phospholipid metabolic process [TAS]
- positive regulation of early endosome to late endosome transport [ISS]
- protein dephosphorylation [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.
3-M primordial dwarfism is an inherited disease characterized by severe pre- and postnatal growth retardation and by mutually exclusive mutations in three genes, CUL7, OBSL1, and CCDC8. The mechanism underlying 3-M dwarfism is not clear. We showed here that CCDC8, derived from a retrotransposon Gag protein in placental mammals, exclusively localized on the plasma membrane and was phosphorylated by CK2 ... [more]
J. Clin. Invest. Jul. 25, 2019; 130();4393-4407 [Pubmed: 31343991]
Throughput
- High Throughput
Curated By
- BioGRID