BAIT
CUL9
H7AP1, PARC, RP3-330M21.2
cullin 9
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCKAP1
HEM2, NAP1, NAP125, p125Nap1
NCK-associated protein 1
GO Process (7)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rac protein signal transduction [IDA]
- apoptotic process [TAS]
- central nervous system development [TAS]
- innate immune response [TAS]
- positive regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- positive regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.
3-M primordial dwarfism is an inherited disease characterized by severe pre- and postnatal growth retardation and by mutually exclusive mutations in three genes, CUL7, OBSL1, and CCDC8. The mechanism underlying 3-M dwarfism is not clear. We showed here that CCDC8, derived from a retrotransposon Gag protein in placental mammals, exclusively localized on the plasma membrane and was phosphorylated by CK2 ... [more]
J. Clin. Invest. Jul. 25, 2019; 130();4393-4407 [Pubmed: 31343991]
Throughput
- High Throughput
Curated By
- BioGRID