BAIT

CUL9

H7AP1, PARC, RP3-330M21.2
cullin 9
GO Process (3)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

APEX2

APE2, APEXL2, XTH2, ZGRF2, RP5-884M20.3
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

Wang P, Yan F, Li Z, Yu Y, Parnell SE, Xiong Y

3-M primordial dwarfism is an inherited disease characterized by severe pre- and postnatal growth retardation and by mutually exclusive mutations in three genes, CUL7, OBSL1, and CCDC8. The mechanism underlying 3-M dwarfism is not clear. We showed here that CCDC8, derived from a retrotransposon Gag protein in placental mammals, exclusively localized on the plasma membrane and was phosphorylated by CK2 ... [more]

J. Clin. Invest. Jul. 25, 2019; 130();4393-4407 [Pubmed: 31343991]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
APEX2 CUL9
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High1BioGRID
2223152
APEX2 CUL9
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9999BioGRID
3057131

Curated By

  • BioGRID