BAIT

MRAS

2900078C09Rik, AI326250
muscle and microspikes RAS
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

MLLT4

5033403D15Rik, AF6, Af-6, Afadin, Gm314, I-afadin, S-afadin
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6.

Quilliam LA, Castro AF, Rogers-Graham KS, Martin CB, Der CJ, Bi C

M-Ras is a Ras-related protein that shares approximately 55% identity with K-Ras and TC21. The M-Ras message was widely expressed but was most predominant in ovary and brain. Similarly to Ha-Ras, expression of mutationally activated M-Ras in NIH 3T3 mouse fibroblasts or C2 myoblasts resulted in cellular transformation or inhibition of differentiation, respectively. M-Ras only weakly activated extracellular signal-regulated kinase ... [more]

J. Biol. Chem. Aug. 20, 1999; 274(34);23850-7 [Pubmed: 10446149]

Throughput

  • Low Throughput

Curated By

  • BioGRID