BAIT
HES6
AI326893, bHLHb41
hairy and enhancer of split 6
GO Process (5)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription cofactor activity [IDA]
- transcription factor binding [NAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription cofactor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
Mus musculus
PREY
HES1
Hry, bHLHb39
hairy and enhancer of split 1 (Drosophila)
GO Process (74)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- Notch signaling pathway [ISO, NAS, TAS]
- STAT protein import into nucleus [IDA]
- adenohypophysis development [IMP]
- aorta morphogenesis [IMP]
- artery morphogenesis [IMP]
- ascending aorta morphogenesis [IMP]
- auditory receptor cell differentiation [IMP]
- auditory receptor cell fate determination [IMP]
- cardiac neural crest cell development involved in outflow tract morphogenesis [IMP]
- cell adhesion [IGI]
- cell fate commitment [IMP]
- cell maturation [IGI]
- cell migration [IGI]
- cell morphogenesis involved in neuron differentiation [IGI]
- cochlea development [IGI, IMP]
- common bile duct development [IMP]
- embryonic heart tube morphogenesis [IMP]
- forebrain radial glial cell differentiation [ISO]
- hindbrain morphogenesis [IGI]
- in utero embryonic development [IGI]
- labyrinthine layer blood vessel development [IMP]
- lateral inhibition [IMP]
- liver development [IMP]
- lung development [IMP]
- midbrain development [IGI]
- midbrain-hindbrain boundary morphogenesis [IGI]
- negative regulation of auditory receptor cell differentiation [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of forebrain neuron differentiation [ISO]
- negative regulation of glial cell proliferation [IDA]
- negative regulation of inner ear receptor cell differentiation [IMP]
- negative regulation of neuron differentiation [IGI, IMP]
- negative regulation of oligodendrocyte differentiation [IDA]
- negative regulation of pancreatic A cell differentiation [IMP]
- negative regulation of pro-B cell differentiation [ISO]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of stomach neuroendocrine cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- negative regulation of transcription, DNA-templated [IMP, ISO]
- neural tube development [IGI]
- neuronal stem cell maintenance [IMP, ISO]
- oculomotor nerve development [IGI]
- outflow tract morphogenesis [IMP]
- pancreas development [IMP]
- pattern specification process [IGI, IMP]
- pharyngeal arch artery morphogenesis [IMP]
- pituitary gland development [IGI, IMP]
- positive regulation of BMP signaling pathway [IGI]
- positive regulation of DNA binding [IDA]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of astrocyte differentiation [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of mitotic cell cycle, embryonic [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- protein complex assembly [IDA]
- regulation of fat cell differentiation [IMP]
- regulation of neurogenesis [IGI]
- regulation of secondary heart field cardioblast proliferation [IMP]
- regulation of timing of cell differentiation [IMP]
- regulation of timing of neuron differentiation [IGI, IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- smoothened signaling pathway [IDA]
- somatic stem cell maintenance [IMP]
- telencephalon development [IGI, IMP]
- thymus development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trochlear nerve development [IGI]
- vascular smooth muscle cell development [IMP]
- ventricular septum development [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- N-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chaperone binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [NAS]
- DNA binding [IDA]
- N-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chaperone binding [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation.
We have isolated the basic helix-loop-helix (bHLH) gene Hes6, a novel member of the family of mammalian homologues of Drosophila hairy and Enhancer of split. Hes6 is expressed by both undifferentiated and differentiated cells, unlike Hes1, which is expressed only by the former cells. Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription. In addition, ... [more]
Development Jul. 01, 2000; 127(13);2933-43 [Pubmed: 10851137]
Throughput
- Low Throughput
Curated By
- BioGRID