CHRNA7
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- calcium ion transport [IDA, IMP]
- cation transmembrane transport [IDA]
- cellular calcium ion homeostasis [IMP]
- cognition [IMP, NAS]
- ion transmembrane transport [IDA]
- ion transport [NAS]
- memory [NAS]
- negative regulation of tumor necrosis factor production [IDA, IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- signal transduction [IDA]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
- acetylcholine binding [IDA]
- acetylcholine receptor activity [IDA]
- acetylcholine-activated cation-selective channel activity [IDA]
- acetylcholine-gated cation channel activity [IDA]
- beta-amyloid binding [IPI]
- chloride channel regulator activity [IDA]
- protein homodimerization activity [IDA]
- toxic substance binding [IDA]
Gene Ontology Cellular Component
FYN
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell activation [IBA]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [IDA]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transport [NAS]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [IBA]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [TAS]
- feeding behavior [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- learning [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- protein phosphorylation [NAS]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.
Multiple lines of evidence, from molecular and cellular to epidemiological, have implicated nicotinic transmission in the pathogenesis of Alzheimer's disease (AD). Here we show the signal transduction mechanism involved in nicotinic receptor-mediated protection against beta-amyloid-enhanced glutamate neurotoxicity. Nicotine-induced protection was suppressed by an alpha7 nicotinic receptor antagonist (alpha-bungarotoxin), a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002 and wortmannin), and a Src inhibitor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FYN CHRNA7 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID