CD63
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- cellular protein localization [IDA]
- endosome to melanosome transport [IMP]
- pigment granule maturation [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of receptor internalization [IMP]
- regulation of rubidium ion transport [IDA]
- regulation of vascular endothelial growth factor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- endosome lumen [IDA]
- endosome membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intrinsic component of plasma membrane [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- multivesicular body, internal vesicle [IDA]
- plasma membrane [TAS]
- platelet dense granule membrane [TAS]
CD9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma.
CD63 belongs to the Transmembrane 4 superfamily (TM4SF) of membrane proteins whose functions are largely unknown. Previous results have suggested that CD63 may play an important role in the regulation of melanoma progression. To explore the role of CD63 in melanoma we have examined its association with other molecules by immunoprecipitation of CD63 from detergent induced lysates of melanoma cells. ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CD63 CD9 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID