FER
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [IBA, ISS]
- Kit signaling pathway [ISS]
- actin cytoskeleton reorganization [ISS]
- cell adhesion [IBA]
- cell differentiation [IBA]
- cell proliferation [IMP]
- cell-cell adhesion mediated by cadherin [ISS]
- cellular response to insulin stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cellular response to reactive oxygen species [ISS]
- chemotaxis [IBA]
- cytokine-mediated signaling pathway [IMP]
- diapedesis [ISS]
- extracellular matrix-cell signaling [ISS]
- innate immune response [IBA]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [ISS]
- interleukin-6-mediated signaling pathway [IMP]
- intracellular signal transduction [TAS]
- microtubule cytoskeleton organization [IMP]
- mitotic cell cycle [IMP]
- negative regulation of mast cell activation involved in immune response [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISS, TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- regulation of lamellipodium assembly [IDA]
- regulation of mast cell degranulation [IBA]
- regulation of protein phosphorylation [ISS]
- response to lipopolysaccharide [ISS]
- response to platelet-derived growth factor [ISS]
- substrate adhesion-dependent cell spreading [ISS]
- tyrosine phosphorylation of Stat3 protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTTN
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISS]
- cell motility [ISS]
- focal adhesion assembly [ISS]
- intracellular protein transport [IMP]
- lamellipodium organization [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of actin filament polymerization [ISS]
- receptor-mediated endocytosis [ISS]
- regulation of axon extension [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.
Previous characterization of the nonreceptor tyrosine kinase FER identified a tight physical association with the catenin pp120 and led to the suggestion that FER may be involved in cell-cell signaling. To further understand the function of FER, we have continued our analyses of the interaction of FER with pp120 and other proteins. The majority of FER is localized to the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FER CTTN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FER CTTN | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3438893 | |
| FER CTTN | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID