Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I.

Sun J, Kavathas PB

The CD8 molecule is expressed either as an alpha/alpha homodimer or an alpha/beta heterodimer on thymocytes and cytotoxic T cells, and functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. Although CD8alpha/beta heterodimers have been shown to be more effective coreceptors, the precise role of the beta-chain in TCR-mediated thymic maturation and T cell ... [more]

J. Immunol. Dec. 15, 1997; 159(12);6077-82 [Pubmed: 9550407]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

CD8A

Gene Ontology Biological Process

Gene Ontology Molecular Function

MHC class I protein binding [NAS]coreceptor activity [NAS]protein binding [IPI]

Gene Ontology Cellular Component

CD8B