BAIT
ANXA6
ANX6, CBP68
annexin A6
GO Process (2)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RASA1
GAPX, Rasa
RAS p21 protein activator (GTPase activating protein) 1
GO Process (12)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- blood vessel morphogenesis [ISO]
- cell adhesion [NAS]
- mitotic cytokinesis [ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell adhesion [ISO, ISS]
- negative regulation of cell-matrix adhesion [ISO, ISS]
- negative regulation of neuron apoptotic process [ISS]
- positive regulation of Ras GTPase activity [IBA]
- regulation of actin filament polymerization [ISO, ISS]
- signal transduction [ISO, ISS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP.
The CaLB domain is a 43-amino acid sequence motif found in a number of functionally diverse signaling proteins including three Ras-specific GTPase activating proteins (GAPs). In the Ras GTPase activating protein, P120(GAP), this domain has the ability to confer membrane association in response to intracellular Ca2+ elevation. Here we have isolated three proteins, p55, p70, and p120, which interact with ... [more]
J. Biol. Chem. Oct. 04, 1996; 271(40);24333-6 [Pubmed: 8798684]
Throughput
- Low Throughput
Curated By
- BioGRID