ANXA6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RASA1
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- blood vessel morphogenesis [ISO]
- cell adhesion [NAS]
- mitotic cytokinesis [ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell adhesion [ISO, ISS]
- negative regulation of cell-matrix adhesion [ISO, ISS]
- negative regulation of neuron apoptotic process [ISS]
- positive regulation of Ras GTPase activity [IBA]
- regulation of actin filament polymerization [ISO, ISS]
- signal transduction [ISO, ISS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP.
The CaLB domain is a 43-amino acid sequence motif found in a number of functionally diverse signaling proteins including three Ras-specific GTPase activating proteins (GAPs). In the Ras GTPase activating protein, P120(GAP), this domain has the ability to confer membrane association in response to intracellular Ca2+ elevation. Here we have isolated three proteins, p55, p70, and p120, which interact with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID