OCLN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TJP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- adherens junction [IDA]
- apical junction complex [ISO]
- apical part of cell [IDA, ISO]
- apical plasma membrane [IDA]
- apicolateral plasma membrane [IDA]
- basolateral plasma membrane [ISO]
- cell junction [IDA, ISO]
- cell surface [ISO]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cytoplasm [IDA, ISO]
- intercalated disc [IDA]
- intercellular canaliculus [IDA]
- membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, ISO]
- tight junction [IDA, ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.
Occludin is an integral membrane protein localizing at tight junctions (TJ) with four transmembrane domains and a long COOH-terminal cytoplasmic domain (domain E) consisting of 255 amino acids. Immunofluorescence and laser scan microscopy revealed that chick full-length occludin introduced into human and bovine epithelial cells was correctly delivered to and incorporated into preexisting TJ. Further transfection studies with various deletion ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID