Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S

Occludin is an integral membrane protein localizing at tight junctions (TJ) with four transmembrane domains and a long COOH-terminal cytoplasmic domain (domain E) consisting of 255 amino acids. Immunofluorescence and laser scan microscopy revealed that chick full-length occludin introduced into human and bovine epithelial cells was correctly delivered to and incorporated into preexisting TJ. Further transfection studies with various deletion ... [more]

J. Cell Biol. Dec. 01, 1994; 127(6);1617-26 [Pubmed: 7798316]

Throughput

  • Low Throughput

Curated By

  • BioGRID