BAIT
C3
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
complement component 3
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CFP
BFD, PFC, PFD, PROPERDIN
complement factor properdin
GO Process (6)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Expression and characterisation of the thrombospondin type I repeats of human properdin.
Properdin, an upregulator of the alternative complement pathway, is central to deposition of the activated complement fragment C3b on the surfaces of the pathogens, which it achieves by preventing the dissociation of the Bb catalytic subunit from the inherently labile C3bBb complexes. It is also known to bind sulphated glycoconjugates, such as sulphatides. Properdin has an unusual structure formed by ... [more]
Biochim. Biophys. Acta Aug. 13, 2001; 1548(2);265-77 [Pubmed: 11513971]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID