NGFR
Gene Ontology Biological Process
- axon guidance [ISO]
- cellular response to oxidative stress [IMP]
- central nervous system development [ISO]
- circadian regulation of gene expression [ISO, ISS]
- detection of temperature stimulus [ISO]
- glucose homeostasis [ISO, ISS]
- hair follicle morphogenesis [ISO]
- intracellular protein transport [ISO, ISS]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of hair follicle development [ISO]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron projection development [IDA]
- nerve development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell death [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of myelination [IMP]
- positive regulation of neuron death [IDA]
- positive regulation of odontogenesis of dentin-containing tooth [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- programmed cell death [ISO]
- regulation of gene expression [ISO]
- regulation of glucose import in response to insulin stimulus [ISO, ISS]
- regulation of reactive oxygen species metabolic process [IMP]
- response to lipopolysaccharide [IEP]
- response to wounding [IMP]
- sensory perception of pain [IMP]
- signal transduction [IDA, ISO]
- skeletal muscle cell differentiation [IEP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [ISO]
- cell surface [ISO]
- clathrin-coated endocytic vesicle [IDA]
- coated vesicle [IDA]
- cytoplasm [IDA, ISO]
- dendrite membrane [IDA]
- external side of plasma membrane [IDA]
- intracellular [ISO]
- membrane raft [IDA]
- neuronal cell body membrane [IDA]
- neuronal postsynaptic density [ISO]
- nuclear envelope [IDA]
- nucleus [IDA]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- rough endoplasmic reticulum [IDA]
APP
Gene Ontology Biological Process
- adult locomotory behavior [ISO, ISS]
- axon cargo transport [ISO, ISS]
- axon midline choice point recognition [ISO, ISS]
- axonogenesis [ISO, ISS]
- cellular copper ion homeostasis [ISO, ISS]
- cholesterol metabolic process [ISO]
- collateral sprouting in absence of injury [ISO, ISS]
- dendrite development [ISO, ISS]
- endocytosis [ISO, ISS]
- extracellular matrix organization [ISO, ISS]
- forebrain development [ISO]
- ionotropic glutamate receptor signaling pathway [ISO, ISS]
- locomotory behavior [ISO, ISS]
- mRNA polyadenylation [ISO, ISS]
- mating behavior [ISO, ISS]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [ISO]
- neuromuscular process controlling balance [ISO]
- neuron apoptotic process [ISO]
- neuron projection development [ISO, ISS]
- neuron remodeling [ISO, ISS]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of mitotic cell cycle [ISO, ISS]
- positive regulation of peptidase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [ISO, ISS]
- regulation of epidermal growth factor-activated receptor activity [ISO, ISS]
- regulation of gene expression [ISO]
- regulation of multicellular organism growth [ISO, ISS]
- regulation of protein binding [ISO]
- regulation of synapse structure or activity [ISO, ISS]
- regulation of translation [ISO, ISS]
- response to oxidative stress [ISO]
- smooth endoplasmic reticulum calcium ion homeostasis [ISO]
- suckling behavior [ISO]
- synaptic growth at neuromuscular junction [ISO]
- visual learning [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [ISO]
- Golgi apparatus [IDA, ISO, ISS]
- apical part of cell [ISO]
- axon [IDA, ISO, ISS]
- cell [ISO]
- cell surface [IDA, ISO]
- cell-cell junction [ISO]
- ciliary rootlet [ISO]
- cytoplasm [ISO, ISS]
- cytoplasmic vesicle [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO, ISS]
- intracellular [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane raft [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [ISO]
- spindle midzone [ISO]
- synapse [ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.
Selective neuronal vulnerability in neurodegenerative diseases is poorly understood. In Alzheimer's disease, the basal forebrain cholinergic neurons are selectively vulnerable, putatively because of their expression of the cell death mediator p75(NTR) (the common neurotrophin receptor), and its interaction with proapoptotic ligands pro-nerve growth factor and amyloid-beta peptide. However, the relation between amyloid precursor protein (APP) and p75(NTR) has not been ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APP NGFR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID