BAIT

ATG16L1

APG16L, ATG16A, ATG16L, IBD10, WDR30, hCG_1817841
autophagy related 16-like 1 (S. cerevisiae)
Autophagy Project
UPS Project
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CALCOCO2

NDP52
calcium binding and coiled-coil domain 2
Alzheimer's Disease Project
Autophagy Project
UPS Project
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.

Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ

Selective autophagy recycles damaged organelles?and clears intracellular pathogens to prevent their aberrant accumulation. How ULK1 kinase is targeted and activated during selective autophagic events remains to be elucidated. In this study, we used chemically inducible dimerization?(CID) assays in tandem with CRISPR KO lines to systematically analyze the molecular basis of selective autophagosome biogenesis. We demonstrate that ectopic placement of NDP52 ... [more]

Mol. Cell Dec. 18, 2018; 74(2);347-362.e6 [Pubmed: 30853401]

Throughput

  • Low Throughput

Additional Notes

  • Sources of NDP52/CALCOCO2 and ATG16L1 not clear

Curated By

  • BioGRID