BAIT
BAZ1B
WBSCR10, WBSCR9, WSTF
bromodomain adjacent to zinc finger domain, 1B
GO Process (8)
GO Function (6)
GO Component (1)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- chromatin-mediated maintenance of transcription [ISS]
- double-strand break repair [ISS]
- heart morphogenesis [ISS]
- histone phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- regulation of transcription, DNA-templated [ISS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDK12
CRK7, CRKR, CRKRS, RP11-390P24.1
cyclin-dependent kinase 12
GO Process (4)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (?H2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcription-coupled H2AX-pY142 in the DDR. We found that constitutive H2AX-pY142 generated by Williams-Beuren syndrome transcription factor (WSTF) interacts with RNA polymerase II (RNAPII) and is ... [more]
Nucleic Acids Res. Dec. 09, 2018; 47(12);6299-6314 [Pubmed: 31045206]
Throughput
- High Throughput
Curated By
- BioGRID