BAIT
MIB1
DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6
mindbomb E3 ubiquitin protein ligase 1
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
STIL
MCPH7, SIL, RP1-18D14.8
SCL/TAL1 interrupting locus
GO Process (16)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cell proliferation [TAS]
- centrosome duplication [IDA, IMP]
- determination of left/right symmetry [ISS]
- embryonic axis specification [ISS]
- floor plate development [ISS]
- forebrain development [ISS]
- heart looping [ISS]
- in utero embryonic development [ISS]
- mitotic spindle organization [IMP]
- multicellular organism growth [ISS]
- negative regulation of apoptotic process [ISS]
- neural tube closure [ISS]
- neural tube development [ISS]
- notochord development [ISS]
- protein localization to centrosome [IMP]
- smoothened signaling pathway [ISS]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.
MIB1 belongs to the RING domain containing family of E3 ubiquitin ligases. In vertebrates, MIB1 plays an essential role in activation of Notch signaling during development, through the ubiquitination and endocytosis of Notch ligands. More recently, Notch independent functions for MIB1 have been described in centriole homeostasis, dendritic spine outgrowth and directional cell migration. Here we use proximity-dependent biotin identification ... [more]
Sci Rep Dec. 28, 2018; 9(1);12471 [Pubmed: 31462741]
Throughput
- High Throughput
Additional Notes
- assayed using BioID (proximity-dependent biotin identification)
Curated By
- BioGRID