BAIT
CCR5
CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
chemokine (C-C motif) receptor 5 (gene/pseudogene)
GO Process (17)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- MAPK cascade [IEP]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [IDA]
- cellular defense response [TAS]
- cellular response to lipopolysaccharide [IEP]
- chemokine-mediated signaling pathway [IDA, NAS, TAS]
- chemotaxis [TAS]
- dendritic cell chemotaxis [TAS]
- entry into host cell [TAS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IMP]
- signaling [IEP]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARRB1
ARB1, ARR1
arrestin, beta 1
GO Process (22)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- membrane organization [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of GTPase activity [IMP]
- positive regulation of Rho protein signal transduction [IMP]
- positive regulation of histone H4 acetylation [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- stress fiber assembly [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif.
Agonist binding to the CC chemokine receptor 5 (CCR5) induces the phosphorylation of four distinct serine residues that are located in the CCR5 C terminus. We established a series of clonal RBL-2H3 cell lines expressing CCR5 with alanine mutations of Ser(336), Ser(337), Ser(342), and Ser(349) in various combinations and explored the significance of phosphorylation sites for the ability of the ... [more]
J. Biol. Chem. Aug. 23, 2002; 277(34);30769-77 [Pubmed: 12065593]
Throughput
- Low Throughput
Additional Notes
- The interaction was detected using surface plasmon resonance.
Curated By
- BioGRID