BAIT
RAVER1
1300006N24Rik, AA050359, mKIAA1978
ribonucleoprotein, PTB-binding 1
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
PREY
ACTN4
C77391
actinin alpha 4
GO Process (7)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- actin filament bundle assembly [IDA]
- negative regulation of cellular component movement [IDA]
- positive regulation of cellular component movement [IDA, IMP, ISO]
- positive regulation of pinocytosis [IMP]
- protein localization to tight junction [IMP]
- regulation of apoptotic process [ISO]
- tight junction assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell-cell junction [IDA]
- cortical cytoskeleton [IDA]
- cytoplasm [IDA, ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- neuron projection [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
- ribonucleoprotein complex [ISO]
- stress fiber [IDA, ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.
By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin, metavinculin, and alpha-actinin and colocalizes with vinculin/metavinculin and alpha-actinin ... [more]
J. Cell Biol. Nov. 26, 2001; 155(5);775-86 [Pubmed: 11724819]
Throughput
- Low Throughput
Curated By
- BioGRID