BAIT
RAVER1
1300006N24Rik, AA050359, mKIAA1978
ribonucleoprotein, PTB-binding 1
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Mus musculus
PREY
ACTN2
1110008F24Rik
actinin alpha 2
GO Process (12)
GO Function (14)
GO Component (7)
Gene Ontology Biological Process
- focal adhesion assembly [ISO]
- microspike assembly [ISO]
- muscle contraction [IDA]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of potassium ion transport [ISO]
- negative regulation of protein localization to cell surface [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of receptor activity [IDA]
- protein homotetramerization [ISO]
- regulation of membrane potential [ISO]
- regulation of nucleic acid-templated transcription [IDA]
Gene Ontology Molecular Function- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
- FATZ binding [ISO]
- LIM domain binding [IPI]
- actin filament binding [IDA, TAS]
- cytoskeletal protein binding [IDA, ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein dimerization activity [ISO]
- protein homodimerization activity [TAS]
- thyroid hormone receptor coactivator activity [IDA]
- titin Z domain binding [ISO]
- titin binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.
By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin, metavinculin, and alpha-actinin and colocalizes with vinculin/metavinculin and alpha-actinin ... [more]
J. Cell Biol. Nov. 26, 2001; 155(5);775-86 [Pubmed: 11724819]
Throughput
- Low Throughput
Curated By
- BioGRID